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Filtered Search Results
Cayman Chemical ANTIBODY H-151 50mg
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A STING inhibitor; forms an adduct with mouse STING in serum and acts in an irreversible manner; inhibits the type I IFN response in vitro; reduces phosphorylation of TBK1 and palmitoylation of hsSTING; reduces CMA-induced increases in mouse serum levels of IFN-β and IL-6
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Cayman Chemical GC7 sulfate 5mg
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A deoxyhypusine synthase inhibitor (Ki = 9.7 nM); inhibits the production of hypusine in CHO cells at 1 µM; inhibits activation of eIF5A2 and enhances the cytotoxicity of doxorubicin in Huh7 and HepG2 cells at 20 µM; reduces tumor growth in a Melan-a Tm5 murine melanoma model at 0.9 mg/kg
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Cayman Chemical GnglIosIde GD1bbovInam 5mg
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A mixture of ganglioside GD1b molecular species isolated from bovine brain with primarily C18:0 fatty acyl chain lengths; a component of plasma membranes; packs densely with cholesterol to form lipid microdomains that modulate both intra- and intercellular signaling events; the concentration of ganglioside GD1b in human brain increases with age
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Cayman Chemical ANTIBODY K02288 50mg
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An ALK1 and ALK2 inhibitor (IC50s = 1.8 and 1.1 nM, respectively) that can prevent BMP4-induced SMAD1/5/8 pathway activation in vitro (IC50 = 100 nM) without affecting TGF-β signaling; less selective for ALK3, 4, 5, and 6 subtypes and the type II BMP receptor ActRIIA (IC50s = 34.4, 302, 321, 6.4, and 220 nM, respectively)
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![Medchemexpress LLC 1-[3-[(5,6,7,8-tetrahydrobenzothieno[2,3-d]pyrimidin-4-yl)oxy]phenyl]ethanone | 298207-77-9 | 99.0% | 324.40 | C18H16N2O2S | 5mg](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000268544.png-250.jpg)
Medchemexpress LLC 1-[3-[(5,6,7,8-tetrahydrobenzothieno[2,3-d]pyrimidin-4-yl)oxy]phenyl]ethanone | 298207-77-9 | 99.0% | 324.40 | C18H16N2O2S | 5mg
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VEGFR-2-IN-37 (compound 12) is an inhibitor of VEGFR-2 The inhibition rate at 200 M was approximately 56 9 M VEGFR-2-IN-37 is a potential inhibitor of human umbilical vein endothelial cell (HUVEC) proliferation[1]
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Cayman Chemical PenIcolInate A 5mg
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A fungal metabolite with diverse biological activities; exhibits antimalarial and antituberculosis activity (MICs = 3.25 and 12.5 mg/ml for P. falciparum and M. tuberculosis H37Ra, respectively); cytotoxic to MCF-7, KB, NCI-H187, and Vero cells (IC50s = 7.49, 18.43, 4.4, and 14.08 μM, respectively)
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Abcam SAG hydrochloride, Smo activator, 5MG
MW 562.98 g/mol, Purity >98%. Potent Smo activator (EC₅₀ = 3 nM, NIH 3T3-derived Shh-LIGHT2 cells). Interacts with the heptahelical domain (Kd = 59 nM). Behaves as an activator at low concentrations and as an inhibitor at high concentrations. Water soluble version of SAG (ab142160).
The product is subject to the following: Abcam Restricted Use Statement
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Abcam Decylubiquinone (2,3-Dmdb), MPTP inhibitor, 10MG
MW 322.4 Da, Purity >98%. Decylubiquinone (2,3-Dmdb), MPTP inhibitor. Achieve your results faster with highly validated, pure and trusted compounds.
The product is subject to the following: Abcam Restricted Use Statement
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Abcam HPI-1, hedgehog signaling inhibitor, 25MG
MW 463.5 Da, Purity >98%. Potent hedgehog signaling inhibitor (IC₅₀ values are 1.5 (Shh), 1.5 (SAG), 4 (Gli2) and 6 μM (Gli1)). Antitumor agent. Active in vivo and in vitro..
The product is subject to the following: Abcam Restricted Use Statement
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Cayman Chemical ANTIBODY GSK-F1 10mg
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A PI4KIIIα inhibitor (IC50 = 5.01 nM); selective for PI4KIIIα over PI4Kβ, PI3Kα, PI3Kβ, PI3Kδ, and PI4Kγ (IC50s = 1,000, 2,512, 7,943, 2,512, and 2,512 nM, respectively); inhibits replication of HCV genotypes 1a, 1b, and 2a in a cell-based replicon assay (IC50s = 12.6, 2.51, and 12.6 nM, respectively)
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Cayman Chemical ANTIBODY IPPD 100g
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A substituted p-phenylenediamine; reduces SOD and CAT activity in zebrafish larvae; reduces heart rate and induces cardiac malformations in zebrafish embryos at 300 UG/L; reduces the swimming speed of zebrafish larva at 2 and 300 UG/L but not 20 UG/L; has been found in rubber boots, particulate matter 2.5 (PM2.5), wastewater influent, effluent, and biosolids, and human milk
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Cayman Chemical FlavoxatehydrochlorIde 5mg
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An inhibitor of L-type calcium channels and an antimuscarinic agent; induces relaxation of potassium-precontracted isolated human urinary bladder detrusor muscle (IC50 = 2 µM) and reduces carbachol- or calcium-induced contractions in isolated rat detrusor strips; inhibits reflex micturition in decerebrated cats when microinjected into the oral pontine reticular nucleus at 0.68 UG/animal
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Cayman Chemical ANTIBODY GSA 10 5mg
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A SMO agonist that can promote the differentiation of multipotent mesenchymal progenitor cells into osteoblasts (EC50 = 1.2 µM); used to characterize a novel SMO active site since it does not recognize the classic cyclopamine binding site utilized by other SMO agonists
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Enzo Life Sciences dBET6 (100mg). CAS: 1950634-92-0
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dBET6 is chemical degrader of BET bromodomain proteins based on PROTAC and led a collapse of global elongation that phenocopies CDK9 inhibition. Purity: ≥99%. Solubility: Soluble in DMSO (240 mg/mL). Insoluble in water. Long Term Storage: -20°C.
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Enzo Life Sciences dBET6 (1mg). CAS: 1950634-92-0
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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dBET6 is chemical degrader of BET bromodomain proteins based on PROTAC and led a collapse of global elongation that phenocopies CDK9 inhibition. Purity: ≥99%. Solubility: Soluble in DMSO (240 mg/mL). Insoluble in water. Long Term Storage: -20°C.
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