Bioactive Small Molecules
Medchemexpress LLC N1,N5-Bis-boc-spermidine | 68076-39-1 | 99.8% | 345.48 | 500 MG
N1,N5-Bis-Boc-spermidine is a linker molecule characterized by an amino group and two Boc-protected amino groups. The amino group is reactive with various functional groups such as carboxylic acids, activated NHS esters, and carbonyls (ketone, aldehyde). The Boc protecting groups can be removed under mild acidic conditions to yield the free amine.
- Reactive amino group for conjugation with carboxylic acids, activated NHS esters, and carbonyls.
- Boc protecting groups can be deprotected under mild acidic conditions.
- Suitable for laboratory centrifugation and storage.
Selleck Chemical LLC Sphingosine-1-phosphate E1999-1MG
Sphingosine-1-phosphate (S1P) is an agonist of S1P1-5 receptors and a ligand of GPR3 GPR6 and GPR12 Sphingosine-1-phosphate is an intracellular second messenger and mobilizes Ca2 as an extracellular ligand for G protein-coupled receptors Sphingosine-1-phosphate is an important lipid mediator generated from Sphingomyelin or other membrane phospholipids
Medchemexpress LLC LDN-209929 dihydrochloride | 1784281-97-5 | 98.3% | 405.77 | 100 MG
LDN-209929 dihydrochloride is a potent and selective haspin kinase inhibitor (IC50=55 nM) with 180-fold selectivity verses DYRK2 (IC50=9.9 μM). It is an optimized analogue of LDN-192960. This compound targets haspin kinase, a serine/threonine kinase crucial in mitosis, and also inhibits DYRKs, a family of kinases involved in various cellular processes.
- Potent and selective haspin kinase inhibitor
- IC50 of 55 nM for haspin kinase
- 180-fold selectivity versus DYRK2
- IC50 of 9.9 μM for DYRK2
- Optimized analogue of LDN-192960
- Suitable for research in metabolic or endocrine disease, cancer, lipid metabolism, and obesity
- Targets protein tyrosine kinase/RTK and haspin kinase pathways
Cayman Chemical Acridine Orange 10-nonyl (bromide), Purity: ≥90%, CAS: 75168-11-5, 5 mg
A mitochondrial dye; incorporates into the cardiolipin-rich inner mitochondrial membrane; selectively binds to cardiolipin-containing liposomes over phosphatidylserine- and phosphatidylinositol-containing liposomes in vitro (Kas = 0.002, 7,000, and 7,000 mM, respectively); binding dependent on mitochondrial membrane potential; ex/em = 490/510 nm, respectively; has been used to quantify cardiolipin content and mitochondrial mass in isolated mitochondria and cellular systems
Medchemexpress LLC Astringin | 29884-49-9 | 1 ML
Astringin is an orally active natural flavonoid compound. It inhibits the production of oxidative stress and inflammatory factors. This compound has multiple activities, including anti-oxidation, anti-inflammation, and anti-apoptosis, and is also an inhibitor of ferroptosis. Astringin can be used in the research of diseases such as acute lung injury.
- Inhibits oxidative stress and inflammatory factors
- Exhibits anti-oxidation, anti-inflammation, and anti-apoptosis activities
- Functions as an inhibitor of ferroptosis
- Suitable for research on diseases like acute lung injury
Selleck Chemical LLC Bentamapimod S8867-2MG
Bentamapimod (AS602801) is a novel orally active JNK inhibitor with IC50 values of 80 nM 90 nM and 230 nM for JNK1 JNK2 and JNK3 respectively
Medchemexpress LLC Methyl (2S)-3-(1-benzylimidazol-4-yl)-2-[(5-methoxy-6-phenylmethoxy-1H-indole-2-carbonyl)am... | 1598424-76-0 | 99.0% | 5MG
Methyl (2S)-3-(1-benzylimidazol-4-yl)-2-[(5-methoxy-6-phenylmethoxy-1H-indole-2-carbonyl)am... | 1598424-76-0 | 99.0% | 5MG
Cayman Chemical Avacopan, Purity: ≥95%, CAS: 1346623-17-3, 10 mg
A C5a1 receptor antagonist (IC50 = 0.1 nM); selective for C5a1 over the C5a2 receptor and CMKLR2 (IC50s = >10,000 nM for both), as well as the C3a receptor, CMKLR1, and FPR1 (IC50s = >10,000 nM for all), and over panels of 18 chemokine receptors (IC50s = ≥6,700 nM for all), 54 other receptors at 10 µM, and five CYP isoforms (IC50s = >10,000 nM for all); reduces the migration of isolated cynomolgus monkey neutrophils at 50 nM; reduces C5a-induced increases in CD11b levels on neutrophils in isolated whole blood from human C5AR1 knock-in mice at 10 and 100 nM or at 0.075 and 0.15 mg/kg
Medchemexpress LLC PF-02413873 (PF-2413873) | 936345-35-6 | 99.9% | 359.44 | 50 MG
PF-02413873 is a potent selective, fully competitive, and orally active nonsteroidal progesterone receptor (PR) antagonist, with a Ki of 2.6 nM. It can block progesterone binding and PR nuclear translocation, and inhibit endometrial growth in vivo.
- Potent selective, fully competitive, and orally active nonsteroidal progesterone receptor (PR) antagonist.
- Ki of 2.6 nM.
- Can block progesterone binding and PR nuclear translocation.
- Can inhibit endometrial growth in vivo.
- Shows potent PR antagonist activity with a derived Ki of 9.7 nM in the T47D native functional assay.
- Induces nuclear translocation only at high concentrations (>3 μM) in vitro.
- Induces a statistically significant reduction in endometrial thickness in cynomolgus macaques.
- Exhibits t1/2 (4.2 h), Cmax (162 ng/mL), and CL/F (41 mL/min/kg) in cynomolgus macaques.
Medchemexpress LLC Enrofloxacin (monohydrochloride) | 93106-59-3 | 99.7% | 500 MG
Enrofloxacin monohydrochloride is an effective antibiotic with an MIC90 of 0.312 μg/mL for Mycoplasma bovis. It also exhibits inhibitory activity against vaccinia virus (VV). This product is for research use only.
- Effective antibiotic
- Exhibits inhibitory activity against vaccinia virus (VV)
- Shows an MIC90 of 0.312 μg/mL for Mycoplasma bovis
- Stable under recommended storage conditions
Cayman Chemical Glutaurine, Purity: ≥90%, CAS: 56488-60-9, 50 mg
A dipeptide; enhances potassium-induced release of L-glutamate and inhibits kainate-induced formation of cGMP in isolated mouse cerebral cortical slices at 0.1 and 1 mM, respectively; decreases plasma levels of T3 and increases plasma TSH levels in rats at 600 µg/kg; prevents electroconvulsive shock-induced amnesia in rats at 50 µg/animal, p.o.
Selleck Chemical LLC BAY-593 E1976-25MG
BAY-593 is an in vivo probe and small molecule inhibitor of geranylgeranyltransferase-I (GGTase-I) blocking oncogenic YAP1/TAZ It exhibits potent anti-tumor activity and inhibits cancer cell proliferation in vitro
Medchemexpress LLC Frangufoline | 19526-09-1 | 98.4% | 1 MG
Frangufoline is a 4(14)-type cyclopeptide alkaloid isolated from the root bark of Ziziphus cambodiana Pierre. It is provided as a purified small-molecule research reagent (CAS 19526-09-1) with reported molecular weight 534.69 g/mol and high purity for biochemical studies.
- 4(14)-type cyclopeptide alkaloid isolated from plant root bark.
- High purity suitable for biochemical and pharmacological research.
- Supplied in small quantities for screening and structure-activity studies.
- Storage: store at 4°C and protect from light; in solvent, keep at -80°C (6 months) or -20°C (1 month).
- Provided with data sheet, certificate of analysis, and safety data sheet.
Medchemexpress LLC 1-Octanamine, N-octyl- | 1120-48-5 | 99.36% | 241.46 | 10 G
Dioctylamine (Di-n-octylamine) is a chemical reagent that features a secondary amine linked to two saturated C8 tails. This secondary amine acts as a versatile substrate, capable of building a wide variety of bonds. Compounds like Dioctylamine may be utilized as intermediates in the construction of lipids for application in lipid nanoparticles.
- It is a chemical reagent featuring a secondary amine linked to two saturated C8 tails.
- The secondary amine is a versatile substrate which can be used to build a wide variety of bonds.
- It may be used as an intermediate in building lipids for use in lipid nanoparticles.
Cayman Chemical Wnt Agonist I, Purity: ≥98%, CAS: 853220-52-7, 50 mg
A cell-permeable activator of Wnt signaling that does not inhibit GSK3β (IC50 > 60 µM); induces nuclear accumulation of β-catenin, increasing transcriptional activity driven by TCF (EC50 = 700 nM)